2016-01-30 19:24:18

论文题目：
Different evolutionary patterns of SNPs between domains and unassigned regions in human protein‐coding sequences
作者：
Erli Pang
文章摘要：

Protein evolution plays an important role in the evolution of each genome. Because of their functional nature, in general, most of their parts or sites are differently constrained selectively, particularly by purifying selection. Most previous studies on protein evolution considered indi- vidual proteins in their entirety or compared protein-coding sequences with non-coding sequences. Less attention has been paid to the evolution of different parts within each pro- tein of a given genome. To this end, based on PfamA anno- tation of all human proteins, each protein sequence can be split into two parts: domains or unassigned regions. Using this rationale, single nucleotide polymorphisms (SNPs) in protein-coding sequences from the 1000 Genomes Project were mapped according to two classi cations: SNPs occur- ring within protein domains and those within unassigned regions. With these classi cations, we found: the density of synonymous SNPs within domains is signi cantly greater than that of synonymous SNPs within unassigned regions; however, the density of non-synonymous SNPs shows the opposite pattern. We also found there are signatures of puri- fying selection on both the domain and unassigned regions. Furthermore, the selective strength on domains is signi - cantly greater than that on unassigned regions. In addition, among all of the human protein sequences, there are 117 PfamA domains in which no SNPs are found. Our results highlight an important aspect of protein domains and may contribute to our understanding of protein evolution.

发表年度：
2016
刊物名称：
Mol Genet Genomics
通讯作者：
Kui Lin